Jian Jian Li
School of Health Sciences, Purdue University
E-mail: jjli@purdue.edu
Website: http://www.healthsciences.purdue.edu/people/faculty.php?uid=jjli

Regulation of NF-kB and Mn SOD in Low Dose Radiation Induced Adaptive Responses in Mouse and Human Skin Cells, abstract, description.

Technical Abstracts:

• 2006 Workshops:
  NF-kB Mediated Signaling Network in Low Dose X-Ray Induced Adaptive Protection on Mouse and Human Skin Epithelial Cells
  Ahmed, K.M., Fan, M., Spitz, and Li, J.J.
  
  
• 2005 Workshops:
  Adaptive Response of Mouse Skin Epithelial Cells to Low Dose Ionizing Radiation: Induction of NF-κB, MnSOD, 14-3-3ζ and Cyclin B1.
  Li, J.J., Ahmed, K.M., Fan, M., Dong, S., Spitz, D.R., and Yu, C.-R.
  
  
• 2003 Workshops:
  Gene Expression Profiles of Human Skin Keratinocytes Exposed to Acute and Chronic Ionizing Radiation
  Li, J.J., Ozeki, M., Wang, T., Tamae, D., Nelson, D., Wyrobek, A., and Coleman, M.A.

Publications:

Murley, J.S., Nantajit, D., Baker, K.L., Kataoka, Y., Li, J.J., and Grdina, D.J. (2008) Maintenance of manganese superoxide dismutase (SOD2)-mediated delayed radioprotection induced by repeated administration of the free thiol form of amifostine. Radiation Research 169(5):495-505.

Yu, C.-Y., Wang, L., Khaletskiy, A., Farrar, W.L., Larner, A., Colburn, N.H., and Li, J.J. (2002) STAT3 activation is required for interleukin-6 induced transformation in tumor-promotion sensitive mouse skin epithelial cells. Oncogene 21:39-49-3960.

Liu, L., Zhang, J., Bates, S., Li, J.J., Rhim, J.S., and Pfeifer, G.P. (2005) A methylation profile of in vitro immortalization human cell lines. Int. J. Oncology 26:275-285.

Wang, T., Hu, Y.C., Dong, S.Z., Fan, M., Tamae, D., Ozeki, M., Gao, Q., Gius, D., and Li, J.J. (2005) Co-activation of ERK, NF-κB and GADD45β in response to ionizing radiation. J. of Biological Chemistry 280(13):12593-12601.

Murley, J., Kataoka, Y., Cao, D., Li, J.J., Oberley, L.W., and Grdina, D.J. (2004) Delayed radioprotection via NF- k B mediated induction of Sod2 (MnSOD) in SA-NH tumor cells following exposure to clinically used thiol containing drugs. Radiation Research 162:536-546.

Ozeki, M., Tamea, D., Hou, D.X., Wang, T., LeBon, T., Spitz, D.R., and Li, J.J. (2004) Response of cyclin B1 to ionizing radiation: Regulation by NF- k B and mitochondrial antioxidant enzyme MnSOD. Anticancer Research 24:2657-2663.

Gou, G., Wang, T., Gao, Q., Tamae, D., Wong, P., Chen, T., Chen, W.-C., Shively, J.E., Wong, J.Y.C., and Li, J.J. (2004) Expression of ErbB2 enhances radiation-induced NF-κB activation. Oncogene 23:535-545.

Spitz, D.R., Azzam, E.I., Li, J.J., and Gius, D. (2004) Metabolic oxidation/reduction reactions and cellular responses to radiation: A unifying concept in stress response biology. Cancer and Metastasis Reviews 23:311-322.

Xia, L., Paik, A., and Li, J.J. (2004) p53 Activation in chronic radiation-treated breast cancer cells. Regulation of MDM2/p14ARF. Cancer Research 64(1):221-228.

Chen, X., Shen, B., Xia, L., Khaletzkiy, A., Chu, D., Wong, J.Y.C., and Li, J.J. (2002) Activation of nuclear factor kB in radioresistance of TP53-inactive human keratinocytes. Cancer Research 62:1213-1221.

Li, Z., Xia, L., Lee, L.M., Khaletskiy, A., Wang, J., Wong, J.Y.C., and Li, J.J. (2001) Effector genes altered in MCF-7 human breast cancer cells after exposure to fractionated ionizing radiation. Radiation Research 155:543-553.

Li, Z., Khaletskiy, A., Wang, J., Wong, J.Y.C., Oberley, L.W., and Li, J.J. (2001) Genes regulated in human breast cancer cells overexpressing manganese-containing superoxide dismutase. Free Radical Biology & Medicine 30(3):260-267.

Guo, G., Yan-Sanders, Y., Lyn-Cook, B.D., Wang, T., Tamae, D., Ogi, J., Khaletskiy, A., Li, Z., Weydert, C., Longmate, J.A., Huang, T.-T., Spitz, D.R., Oberley, L.W., and Li, J.J. (2003) Manganese superoxide dismutase-mediated gene expression in radiation-induced adaptive responses. Molecular and Cellular Biology 23:2362-2378.

Wang, T., Zhang, X., and Li, J.J. (2002) The role of NFKB in the regulation of cell stress responses. International Immunopharmacology 2(11):1509-1520.

Xufeng, C., Shen, B., Xia, L., Khaletzkiy, A., Chu, D., Wong, J.Y.C., and Li, J.J. (2002) Activation of nuclear factor KB in radioresistance of TP53-inactive human keratinocytes. Cancer Research 62(4):1213-1221.

Li, J.J., Cao, Y., Young, M.R., and Colburn, N.H. (2000) Induced expression of dominant-negative c-jun downregulates NFKB and AP-1 target genes and suppresses tumor phenotype in human keratinocytes. Molecular Carcinogenesis 29:159-169.

Ding, M., Li, J.J., Leonard, S.S., Ye, J-P, Shi, X., Colburn, N.H., Castranova, V., and Vallyathan, V. (1999) Vanadate-induced activiation of activator protein-1: Role of reactive oxygen species. Carcinogenesis 20(4):663-668.

Li, J.J., Rhim, J.S., Schlegel, R., Vousde, K.H., and Colburn, N.H. (1998) Expression of dominant negative Jun inhibits elevated AP-1 and NFKB transactivation and suppresses anchorage independent growth of HPV immortalized human keratinocytes. Oncogene 16(21):2711-2721.