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David
J. Chen
DHChen@lbl.gov
Lawrence
Berkeley National Laboratory
Currently
Funded Projects:
Radiation
response in Normal HSF (Human Skin Fibroblasts): cDNA Microarray
Analysis.
Golder-Novoselsky, E., Ding, L-H., Chen, F. and Chen,
D.J.
Defining
Responses to Low Level Ionizing Radiation in Mammalian Cells.
Nagasawa, H., Little, J. and Chen, D.J.
Mechanisms
of DNA Damage Responses to Low Level Ionizing Radiation.
Rydberg, B., Chernikova, S., Pluth, J., Chen,
D.J. and Cooper, P.K.
Mechanisms
of DNA Damage Responses to Low Dose Ionizing Radiation:
Molecular, Biochemical, and Cellular Studies.
Cooper, P.K., Chen, D.J.,
Meuth, M. and Rydberg, B.
Publications:
Nagasawa, H., Wilson, P.E., Chen,
D.J., Thompson, L.H., Bedford,
J.S., and Little, J.B. (2008)
Low doses of alpha particles do not induce sister chromatid
exchanges in bystander Chinese hamster cells defective
in homologous recombination. DNA Repair 7(3):515-522.
Uematsu, N., Chen, B.P., Jakob, B., Taucher-Scholz, G., and Chen, D.J. (2006) Session 5. Dynamics of DSB sensing repair proteins at DNA double-strand breaks in living cells. In: Proceedings of the 7th International Workshop: Microbeam Probes of Cellular Radiation Response.Radiation Research 166:677-678.
Yang, F., Stenoien, D.L., Strittmatter, E.F., Wang, J., Ding, L., Lipton, M.S., Monroe, M.E., Nicora, C.D., Gristenko, M.A., Tang, K., Fang, R., Adkins, J.N., Camp, D.G. II, Chen, D.J. and Smith, R.D. (2006) Phosphoproteome profiling of human skin fibroblast cells in response to low- and high-dose irradiation. Journal of Proteome Research 5:1252-1260.
Al Rashid, S.T., Dellaire, G., Cuddihy, A., Jalali, F., Vaid, M., Coackley, C., Folkard, M., Xu, Y., Chen, B.P.C., Chen, D.J., Lilge, L., Prise, K.M., Jones, Bazett Jones, D.P. and Bristow, R.G. (2005) Evidence for the direct binding of phosphorylated p53 to sites of DNA breaks in vivo. Cancer Research 65(23):10810-10821.
Nagasawa, H., Peng, Y., Wilson, P.F., Lio, Y-C., Chen, D.J., Bedford, J.S., and Little, J.B. (2005) Role of homologous recombination in the alpha-particle-induced bystander effect for sister chromatid exchanges and chromosomal aberrations. Radiation Research 164:141-147.
Ding, L-H., Shingyoji, M., Chen, F., Hwang, J-J., Burma, S., Lee, C., Cheng, J-F., and Chen, D.J. (2005) Gene expression profiles of normal human fibroblasts after exposure to ionizing radiation: A comparative study of low and high doses. Radiation Research 164:17-26.
Izumi, T., Brown, D.B., Naidu, C.V., Bhakat,
K.K., MacLnnes, M.A., Saito, H., Chen, D.J., and
Mitra, S. (2005) Two essential but distinct functions of
the mammalian abasic endonuclease. PNAS 102(16): 5739-5743.
Donoh, G., Brenneman, M.A., Cui, T.X.,
Donoviel, D., Vogel, H., Goodwin, E.H., Chen, D.J., and
Hasty, P. (2003) Deletion of Brca2 exon 27 causes
hypersensitivity to DNA crosslinks, chromosome instability,
and reduced life span in mice. Genes, Chromosomes, & Cancer 36: 317-331.
Burma, S., Chen, B.P., Murphy, M., Kurimasa, A., and Chen, D.J. (2001)
ATM phosphorylation histone H2AX in reponse to DNA double-strand breaks. The
Journal of Biological Chemistry 276(45):42462-42467.
Burma,
S., Chen, D.J. (2004) Role of
DNA-PK in the cellular responses to DNA double-strand
breaks. DNA
Repair 3:909-918.
Lio,
Y-C., Schild, D., Brenneman, M.A., Redpath,
J.L., and Chen, D.J. (2004) Human
Rad51C deficiency destabilizes XRCC3, impairs recombination,
and radiosensitizes S/G2-phase cells. J. Biol. Chem. 279(40): 42313-42320.
Wechsler,
T., Chen, B.P.C., Harper, R., Morotomi-Yano, K., Huang,
B.C.B., Meek, K., Cleaver, J.E., Chen, D.J.,
and Wabl, M. (2004) DNA-PKcs function regulated specifically
by protein phosphatase 5. PNAS 101(5):1247-1252.
Little,
J.B., Nagasawa, H., Li, G.C., and Chen, D.J.
(2003) Involvement of the nonhomologous end joining DNA
repair pathway in the bystander effect for chromosomal aberrations.
Radiation Research 159(2):262-267
Little,
J.B., Nagasawa, H., Dahlberg, W.K., Zdzienicka, M.Z., Burma
S., and Chen, D.J. (2002) Differing responses of
Nijmegen Breakage Syndrome and Ataxia telangiectasia
cells to ionizing radiation. Radiation Research
158:319-326.
Nimura,
Y., Ismail, S.M., Kurimas, A., Chen, D.J., and Stevens,
C.W. (2002) DNA-PK and ATM are required for radiation-enhanced
integration. Rad. Res. 157:562-567.
Bailey,
S.M., Cornforth, M.N., Kurimasa, A., Chen, D.J.,
and Goodwin, E.H. (2001) Strand-specific postreplicative
processing of mammalian telomeres. Science 293:2462-2465.
Hayata,
I., Wang, C., Zhang, W. Chen, D., Minamisamatsu, M., Morishima,
H., Yuan, Y., Wei, L., and Sugahara, T. (2000) Chromosome
translocation in residents of the high background radiation
areas in southern China. J. Radiat. Res.
41:69-74.
Jiang,
T., Hayata, I., Wang, C., Nakai, S., Yao, S., Yuan, Y.,
Dai, L., Liu, Q., Chen, D., Wei, L., and Sugahara, T. (2000)
Dose-effect relationship of dicentric and ring chromosomes
in lymphocytes of individuals living in the high background
radiation areas in China. J. Radiat. Res. 41:63-68.
Bailey,
S.M., Meyne, J., Chen, D.J., Kurimasa,
A., Li, G.C., Lehnert, B.E., and Goodwin,
E.H. (1999) DNA double-strand break repair proteins
are required to cap the ends of mammalian chromosomes.
PNAS 96(26):14899-14904.
Liu,
N., Lamerdin, J.E., Tebbs, R.S., Schild, D., Tucker, J.D.,
Shen, M.R., Brookman, K.W., Siciliano, M.J., Walter, C.A.,
Fan, C.A., Narayana, L.S., Zhou, Z.Q., Adamson, A.W., Sorensen,
K.J., Chen, D.J., Jones, N.J., and Thompson, L.H. (1998)
XRCC2 and XRCC3, new human Rad51-family members, promote
chromosome stability and protect against DNA crosslinks
and other damages. Mol. Cell. 1:783-793.
Gadbois,
D.M., Crissman, H.A., Nastasi, A., Habbersett, R., Wang,
S., Chen, D., and Lehnert, B.E. (1996) Alterations in the
progression of cells through the cell cycle after exposure
to alpha particles or gamma rays. Radiation Research
146:414-424
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