Robert L. Ullrich
Colorado State University
E-mail: bullrich@colostate.edu
Website: http://www.cvmbs.colostate.edu/radiology/Ullrich/ullrich.html

Currently Funded Projects:

Radiation Leukemogenesis at Low Dose Rates (NSCOR)

Genetic Mechanisms of Induced Chromosomal Instability and their Relationships with Radiation Tumorigenesis

Technical Abstracts:

• 2006 Workshop:
  The Role of Telomere Dysfunction in Driving Genomic Instability
  Bailey, S.M., Williams, E.S., and Ullrich, R.L.
  
  
• 2005 Workshop:
  Dsyfunctional Mammalian Telomeres in DNA-PKcs Deficient Backgrounds
  Bailey, S.M., Williams, E., Hagelstrom, T., and Ullrich, R.L.
  
• 2003 Workshop:
  Dysfunctional Mammalian Telomeres Join to Double-Strand Breaks
  Bailey, S.M., Goodwin, E.H., Williams, E., and Ullrich, R.L.
  
  
• 2002 Workshop:
  Dysfunctional Telomeres, Radiation-Induced Instability and Tumorigenesis Bailey, S.M., Goodwin, E.H., Cornforth, M.N., and Ullrich, R.L.

Publications:

Zhang, Y., Zhou, J.Q., Cao, X.F., Zhang, Q., Lim, C.U.K., Ullrich, R.L., Bailey, S.M., and Liber, H.L. (2007) Partial deficiency of DNA-PKcs increases ionizing radiation-induced mutagenesis and telomere instability in human cells. Cancer Letters 250(1):63-73.

Bailey, S.M., Williams, E.S., and Ullrich, R.L. (2007) The role of telomere dysfunction in driving genomic instability. International Congress Series. 1299:146-149.

Kronenberg, A., Schubauer-Berigan, M., Colman, M., Darby, S., Gilbert, E., Howe, G., Jones, I., Mossman, K., Ronckers, C., Smith, J., Stram, D., Ullrich. R., and Zimbrick, J. (2007) Radiation research: State of the science twenty years after Chernobyl. Radiation Research 167:338-360.

Malone, J. and Ullrich, R. (2007) Novel radiation response genes identified in gene-trapped MCF10A mammary epithelial cells. Radiation Research 167:176-184.

Brooks, A.L., Coleman, M.A., Douple, E.B., Hall, E., Mitchel, R.E.J., Ullrich, R.L., and Wyrobek, A.J. (2006) Biological Effects of Low Doses of Ionizing Radiation. In: Advances in Medical Physics 1:255-286.

Darakhshan, F., Badie, C., Moody, J., Coster, M., Finnon, R., Finnon, P., Edwards, A.A., Szluinska, M., Skidmore, C.J., Yoshida, K., Ullrich, R., Cox, R., and Bouffler, S.D. (2006) Evidence for complex multigenic inheritance of radiation AML susceptibility in mice revealed using a surrogate phenotypic assay. Carcinogenesis 27(2):311-318.

Pati, D., Haddad, B.R., Haegele, A., Thompson, H., Kittrell, F.S., Shepard, A., Montagna, C., Zhang, N., Ge, G., Otta, S.K., McCarthy, M., Ullrich, R.L., and Medina, D. (2004) Hormone-induced chromosomal instability in p53-null mammary epthelium. Cancer Research 64:5608-5616.

Bailey, S.M., Brenneman, M.A., Halbrook, J., Nickoloff, J.A., Ullrich, R.L., and Goodwin, E.H. (2004) The kinase activity of DNA-PK is required to protect mammalian telomeres. DNA Repair 3:225-233.

Bailey, S.M., Cornforth, M.N., Ullrich, R.L., and Goodwin, E.H. (2004) Dysfunctional mammalian telomeres join with DNA double-strand breaks. DNA Repair 3:349-357.

Ullrich, R.L. (2003) Genomic instability, susceptibility genes, and carcinogenesis. Health Physics 85(1):30.

Medina, D., Ullrich, R., Meyn, R., Wiseman, R., and Donehower, L. (2002) Environmental carcinogens and p53 tumor suppressor gene interactions for mammary carcinogenesis in a transgenic mouse model. Environmental and Molecular Mutagenesis 39:178-183.

Okayasu, R., Suetomi, K., Yu, Y., Silver, A., Bedford, J.S., Cox, R., and Ullrich, R.L. (2000) A deficiency in DNA repair and DNA-PKcs expression in the radiosensitive BALB/c mouse. Cancer Research 60:4342-4245.

Ponnaiya, B., Cornforth, M.N., and Ullrich, R.L. (1997) Induction of chromosomal instability in human mammary cells by neutrons and gamma rays. Radiation Research 147:288-294.

Ponnaiya, B., Cornforth, M.N., and Ullrich, R.L. (1997) Radiation-induced chromosomal instability in BALB/c and C57BL/6 mice: The difference is as clear as black and white. Radiation Research 147:121-125.