Principle Investigators for the Low Dose Radiation Research Program

Daila S. Gridley
School of Medicine, Department of Microbiology and Molecular Genetics
Loma Linda University
E-mail: dgridley@dominion.llumc.edu
Website: http://www.llu.edu/llu/medicine/micro/faculty/gridley.htm

Newly Funded Projects:

Mechanisms of Low Dose Radiation-Induced T Helper Cell Function Abstract. Description.

Technical Abstracts:

2006 Workshop:
Low Dose Photon Radiation-Induced Changes in T Helper Lymphocytes
Gridley, D.S., Rizvi, A., Luo, X., Makinde, A.Y., Rightnar, S., Tian, J., Andres, M.L., Slater, J.M., and Pecaut, M.J.

Protracted Low Dose Photon and Simulated Solar Flare Proton Effects on Cytokine/Chemokine Expression after Whole-Body Irradiation
Rizvi, A., Coutrakon, G., Slater, J.M., Pecaut, M.J., and Gridley, D.S.
2005 Workshop:
Mechanisms of Low Dose Radiation-induced T Helper Cell Function
Gridley, D.S., Green, L.M., Slater, J.M, and Pecaut, M.J.
Long-Term Effects of Whole-Body, High-LET Radiation on Blood Chemistry
Gridley, D.S., Bateman, T., Hamilton, S.A., Obenaus A., and Pecaut, M.J.

Publications:

Gridley, D.S., Rizvi, A., Luo-Owen, X., Makinde, A.Y., Coutrakon, G.B., Koss, P., Slater, J.M., and Pecaut, M.J. (2008) Variable hematopoietic responses to acute photons, protons and simulated solar particle event protons. In Vivo 22(2):159-169.

Williams, J.R., Zhang, Y., Zhou, H., Gridley, D.S., Koch, C.J., Russell, J., Slater, J.S., and Little, J.B. (2008) A quantitative overview of radiosensitivity of human tumor cells across histological type and TP53 status. International J. of Radiation Biology 84(4):253-264.

Gridley, D.S., Coutrakon, G.B., Rizvi, A., Bayeta, E.J.M., Luo-Owen, X., Makinde, A.Y., Baqai, F., Koss, P., Slater, J.M., and Pecaut, M.J. (2008) Low-dose photons modify liver response to simulated solar particle event protons. Radiation Research 169(3):280-287.

Gridley, D.S., Miller, G.M., and Pecaut, M.J. (2007) Radiation and primary response to lipopolysaccharide: Bone marrow-derived cells and susceptible organs. In Vivo 21(3):453-461.

Gridley, D.S., Dutta-Roy, R., Andres, M.L., Nelson, G.A., and Pecaut, M.J. (2006) Acute effects of iron-particle radiation on immunity. Part II: Leukocyte activation, cytokines and adhesion. Radiation Research 165:78-87.

Pecaut, M.J., Dutta-Roy, R., Smith, A.L., Jones, T.A., Nelson, G.A., and Gridley, D.S. (2006) Acute effects of iron-particle radiation on immunity. Part I: Population distributions. Radiation Research 165:68-77.

Luo, X., Andres, M.L., Timiryasova, T.M., Fodor, I., Slater, J.M., and Gridley, D.S. (2005) Radiation-enhanced endostatin gene expression and effects of combination treatment. Technology in Cancer Research and Treatment 4(2):193-201.

Gridley, D.S., Williams, J.R., and Slater, J.M. (2005) Low-dose/low-dose-rate radiation: A feasible strategy to improve cancer radiotherapy? Cancer Therapy 3:105-130.

Luo, X., Slater, J.M., and Gridley, D.S. (2005) Enhancement of radiation effects by pXLG-mENDO in a lung carcinoma model. Int. J. Radiation Oncology Biol. Phys.63(2):553-564.

Pecaut, M.J., Miller, G.M., Nelson, G.A., and Gridley, D.S. (2004) Hypergravity-induced immunodulation in a rodent model: Hematological and lymphocyte function analysis. J. Appl. Physiol. 97:29-38.

Gridley, D.S., Bonnet, R.B., Bush, D.A., Franke, C., Cheek, G.A., Slater, J.D., and Slater, J.M. (2004) Time course of serum cytokines in patients receiving proton or combined photon/proton beam radiation for resectable but medically inoperable non-small-cell lung cancer. International J. of Radiation: Oncology - Biology - Physics 60(3):759-766

Dicello, J.F., Christian, A., Ctucinotta, F.A., Gridley, D.S., Kathirithamby, R., Mann, J., Markham, A.R., Moyers, M.F., Novak, G.R., Piantdosi, S., Ricart-Arbona, R., Simonson, D.M., Strandberg, J.D., Vazquez, M., Williams, J.R., Zhang, Y., Zhou, H., and Huso, D. (2004) In vivo mammary tumorigenesis in the Sprague-Dawley rat and rnicrodosimetric correlates. Phys. Med. Biol. 49(16):3817-3830.

Pecaut, M.J., Gridley, D.S., Moyers, M.F., Rabin, B., and Nelson, G.A. (2003) "Out-of-field" effects of head-localized proton irradiation on peripheral immune parameters. In Vivo 17:513-522.

Kadhini, M.A., Green, L.M., Gridley, D.S., Murray, D.K., Tran, D.T., Pocock, D., Macdonald, D., Andres, M.A., Moyers, M.F., Goodhead, D.T., and Nelson, G.A. (Dec. 2003). Chapter 6: In vitro studies on space radiation-induced delayed genetic responses: Shielding effects. In: Radiation protection studies of international space station extravehicular activity space suits (F.A. Cucinotta, M.R. Shavers, P.B. Saganti, and J. Miller, eds.). Houston, TX : National Aeronautics and Space Administration and Johnson Space Center, NASA/TP-2003-212051, pp. 105-120 <http://techreports.lasrc.nasa.gov/cgi-bin/NTRS>.

Miller, G.M., Kim, D.W., Andres, M.L., Green, L.M., and Gridley, D.S. (2003) Changes in the activation and reconstitution of lymphocytes resulting from total-body irradiation correlate with slowed tumor growth. Oncology 65(3):229-241.

Timiryasova, T.M., Gridley, D.S., Chen, B., Andres, M.L., Dutta-Roy, R., Miller, G., Bayeta, E.J.M., and Fodor, I. (2003) Radiation enhances the anti-tumor effects of vaccinia-p53 gene therapy in glioma. Technology in Cancer Research and Treatment 2(3):223-235

Miller, G.M., Andres, M.L., and Gridley, D.S. (2003) NK cell depletion results in accelerated tumor growth and attenuates the antitumor effect of total body irradiation. Int. J. Oncol. 23(6):1585-1592.

Pecaut, M.J., Nelson, G.A., Bateman, T.A., Stodieck, L.S., Simske, S.J., Peters, L.L., Morony, S., Kostenuik, P.J., and Gridley, D.S. (2003) Effects of spaceflight on immunity in the C57BU6 mouse, Part 1: Immune population distributions. J. Appl. Physiol. 94:2085-2094. [Featured in "Highlighted Topics" of journal.]

Gridley, D.S., Nelson, G.A., Bateman, T.A., Stodieck, L.S., Simske, S.J., Peters, L.L., Morony, S., Kostenuik, P.J., and Pecaut, M.J. (2003) Effects of spaceflight on immunity in the C57BLJ6 mouse, Part 11: Activation, cytokines, erythrocytes, and platelets. J. Appi. Physiol. 94:2095-2103. [Featured in "Highlighted Topics" of journal.]

Pecaut, M.J., Gridley, D.S., and Nelson, G.A. (2003) Long term effects of low dose whole-body proton irradiation on immunity: Shielded vs unshielded. Aviat. Space Environ. Med. 74:115-124.

Green, L.M., Patel, Z., Murray, D.K., Rightnar, S., Burell, C.G., Gridley, D.S., and Nelson, G.A. (2002) Cytoskeletal and functional changes in bioreactor assembled thyroid tissue organoids exposed to gamma radiation. J. Radiation Research (Tokyo) 43:S213-S218.

Gridley, D.S., Pecaut, M.J., Green, L.M., Miller, G.M., and Nelson, G.A. (2002) Hypergravity-induced immunomodulation in a rodent model: Lymphocytes and lymphoid organs. J. Gravitational Physiol. 9(2):15-28.

George, K., Willingham, V., Wu, H., Gridley, D., Nelson, G., and Cucinotta, F.A. (2002) Chromosome aberrations in human lymphocytes induced by 250 MeV protons: Effects of dose, dose rate and shielding. Adv. Space Res. 30:891-899.

Miller, G.M., Kajioka, E.H., Andres, M.L., and Gridley, D.S. (2002) Dose and timing of total-body irradiation mediate tumor progression and immunomodulation. Oncol. Res. 13:9-18.

Gridley, D.S., Pecaut, M.J., Dutta-Roy, R., and Nelson, G.A. (2002) Dose and dose rate effects of whole- body proton irradiation on feukocyte populations and lymphoid organs: Part 1. Immunol. Letters 80:55-66.

Pecaut, M.J., Gridley, D.S., Smith, A.L., and Nelson, G.A. (2002) Dose and dose rate effects of whole-body proton irradiation on lymphocyte blastogenesis and hematological variables: Part II. Immunol. Letters 80:66-73.

Gridley, D.S., Pecaut, M.J., and Nelson, G.A. (2002) Total-body irradiation with high-LET particles: Acute and chronic effects on the immune system. Am. J. Physiol - Regul Integr Comp. Physiol. 282:R677-R688.

Pecaut, M.J., Nelson, G.A., and Gridley, D.S. (2001) Dose and dose rate effects of whole-body y-irradiation. 1. Lymphocytes and lymphoid organs. In Vivo 15:195-208.

Gridley, D.S., Pecaut, M.J., Miller, G.M., Moyers, M.F., and Nelson, G.A. (2001) Dose and dose rate effects of whole-body y-irradiation: I. Hematological variables and cytokines. In Vivo 15:209-216.

Nelson, G.A., Green, L.M., Gridley, D.S., Archambeau, J.-0., and Slater, J.M. (2001) Research activities at the Loma Linda University and Proton Treatment Facility: An overview. Phys. Med. 17:30-33.

Kajioka, E.H., Andres, M.L., Mao, X.W., Moyers, M.F., Nelson, G.A., and Gridley, D.S. (2000) Hematological and TGF-0 variations after whole-body proton irradiation. In Vivo 14:703-708.

Kajioka, E.H., Andres, M.L., Li, J., Mao, X.W., Moyers, M.F., Nelson, G.A., Slater, J.M., and Gridley, D.S. (2000) Acute effects of whole-body proton irradiation on the immune system of the mouse. Radiation Reseach 153:587-594.

Kajioka, E.H., Andres, M.L., Nelson, G.A., and Gridley, D.S. (2000) Immunological variables in male and female C57BU6 mice from two sources. Comparative Med. 50(3):288-291.

Pecaut, M.J., Smith, A.L., Jones, T.A., and Gridley, D.S. (2000) Modification of immunologic and hematologic variables by method of C02 euthanasia. Comparative Med. 50(6):595-602.

Kajioka, E.H., Gheorghe, C., Li, J., Andres, M.L., Folz-Holbeck J., Abell, G.A., Slater, J.M., Nelson, G.A., and Gridley, D.S. (1999) Effects of proton and gamma radiation on lymphocyte populations and acute response to antigen. In Vivo 13(6):525-533.

Slater, J.M., Braby, L., Dicello, J., Gridley, D.S., Todd, P., and Yang, T.C. (1999) NASA Human Research Facilities: Report of the Radiation Discipline Working Group, Dept. of Radiation Medicine, Loma Linda University Medical Center. Submitted to Johnson Space Center. pp. 1-33.