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Cellular
and Molecular Studies of
Radio-Adaptive Responses
Low Dose Radiation Damage and Radioprotection in the Vertebrate
Embryo
William Dynan
Medical College of Georgia
Augusta, GA 30912
Why
this Project?
To
identify mechanisms that control sensitivity and resistance
to the effects of ionizing radiation in vitro.
- To determine
if radiation-induced apoptosis and other types of cell death
are responsible for the radiation–induced damage in
the central nervous system of the embryo.
- To
investigate the underlying mechanisms of low dose radiation
injury to the embryo.
- To
test the hypothesis that DNA-double strand break repair is
the primary mechanism of protection against radiation-induced
cell death.
Experimental
Approach:
This
study will use the developing embryo of the zebra fish, Danio
rerio, as a new radiobiological model. Cells from these
embryos will be irradiated and trasplanted into non-irradiated
embryos. The impact of the radiated cells on non-irradiated
neighboring cells will be evaluated.
Expected
Outcomes:
The studies
will determine whether radiation-induced alterations in development
occur in vivo are a result of direct damage to an
irradiated cell, or if it can be induced in non-exposed cells
as a bystander effect.
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