Cellular and Molecular Studies of
Radio-Adaptive Responses

Judith Campisi
JCampisi@lbl.gov
Lawrence Berkeley National Laboratory
Website: http://www.lbl.gov/lifesciences/CMB/Campisi.html

To test the hypothesis that in mammalian cells, radiation-induced responses may differ depending on the cell type, growth and/or differentiation status and genotype of the cell.

Project Goals:

1. To explore the mechanisms involved in radiation-induced hormesis,
   
2. To determine if any of these mechanisms result from positive feedback, stimulation of repair and /or cell defense mechanisms

Experimental Approach:

Primary human fibroblast and mammary epithelial cells, as well as the simple multi-cellular nematode, Caenorhabditis elegans will be used to explore these mechanisms. This will make it possible to determine genes involved in expression of adaptive response.

Expected Outcomes:

These studies will provide a broad cellular and genetic framework on which to better understand the genetic regulation of the radio-adaptive response.