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MFISH Measurements of Chromosomal Aberrations in Individuals Exposed
in utero
to Gamma-Ray Doses from
5-20cGY


David J. Brenner
djb3@columbia.edu
Columbia University

Website: http://www.columbia.edu/~djb3/

Why This Project?

The risk for late effects in individuals exposed to low doses of gamma radiation during in utero development has been a concern. This study will measure the chromosome aberration frequency in the blood lymphocytes of individuals that were identified as having been exposed to low doses of gamma rays in utero while their mothers were working at the nuclear facility at Mayak in Russia

Project Goals:

To determine if an excess aberration frequency can be detected in individuals exposed in utero.

Experimental Approach:

To compare the results to sex-gender and age-matched controls, and to compare chromosome aberration frequency in exposed and controls.

Expected Outcomes:

The types and frequency of aberrations will be used to help predict the cancer risks from in utero radiation exposure.

 



                   
                   
                   
 

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