David J. Brenner
Center for Radiological Research, Columbia University
630 W. 168th St., New York, NY 10032
djb@columbia.edu
Website: http://www.columbia.edu/~djb3/

Newly Funded Projects:

mFISH Measurements of Chromosomal Aberrations in Individuals Exposed in Utero to Gamma-Ray Doses from 5-20 cGy

Is Increased Low-Dose Radiosensitivity Associated with Increased Transgenerational Germline Mutation Radiosensitivity?
Abstract. Description.

Studies of Bystander Effects in 3-D Tissue Systems Using a Low-LET Microbeam

Currently Funded Projects:

Significance of the Bystander Effect: Modeling, Experiments, and More Modeling

The Risk of Cancer Induction Due to Routine Mammographic Screening

Technical Abstracts:

• 2006 Workshop
  The Bystander Effect in Normal Human 3-D Tissue: Experiments, Models, and Implications
  Brenner, D., Ponnaiya, B., Shuryak, I., Sachs, R., and Geard, D.
  
  Is Increased Low-Dose Somatic Radiosensitivity Associated with Increased Trans-Generational Germline Mutation Radiosensitivity?
  Dubrova, Y, Weil, M., and Brenner, D. J.
  
  
• 2005 Workshop
  Is Increased Low-Dose Somatic Radiosensitivity Associated with Increased Trans-Generational Germline Mutation Radiosensitivity?
  Dubrova, Y., Weil, M., and Brenner, D.J.
  
  Virtual Colonoscopy: The Potential Benefits of Low-Dose Radiation Exposure Far Outweigh any Risks
  Brenner, D.J.
  
  
• 2003 Workshop:
  Apoptosis in Unirradiated Cells in Human Tissue as a Response to
  Radiation Damage in Cells up to 1 mm Away
  Belyakov, O.V., Randers-Pehrson, G., Mitchell, S.A., Marino, S.A., and Brenner. D.J.

• 2002 Workshop:
  Do Low Dose-Rate Bystander Effects Influence Domestic Radon Risks?
  Brenner, D.J. and Sachs, R.K.

• 2001 Workshop:
  Computer Simulations of Chromosome Aberration Data for Human Cells Subjected to Low-LET Radiation: Mechanistic Implications
  Sachs, R. K., Cornforth, M., Vazquez, M., Arsuaga, J., Hlatky, L., Geard, C., and Brenner, D.J.

• 1999 Workshop:
  Cytogenetic Tests of Radiobiological Models Relating Epidemiologically Measurable Risks to Low-Dose Risks
  Sachs, R.K., Brenner, D.J., Geard, C., and Hlatky, L.
  
  The Risk of Cancer Induction Due to Routine Mammographic Screening
  Brenner, D.J., Marino, S., and Geard, C.

Publications:

Hall, E.J. and Brenner, D.J. (2008) Cancer risks from diagnostic radiology. British J. of Radiology 81(965):362-378.

Brenner, D.J. and Hall, E.J. (2008) Secondary neutrons in clinical proton radiotherapy: A charged issue. Radiotherapy and Oncology 86(2):165-170.

Hodgson, D.C., Koh, E.-S., Tran, T.H., Heydarian, M., Tsang, R., Pintilie, M., Xu, T., Huang, L., Sachs, R.K., and Brenner, D.J. (2007) Individualized estimates of second cancer risks after contemporary radiation therapy for Hodgkin lymphoma. Cancer 110(11):2576-2586.

Sachs, R.K., Shuryak, I., Brenner, D.J., Fakir, H., Hlatky, L., and Hahnfeldt, P. (2007) Second cancers after fractionated radiotherapy: Stochastic population dynamics effects. Journal of Theoretical Biology 249(3):518-531.

Koh, E.S., Tran, T.H., Heydarian, M., Sachs, R.K., Tsang, R.W., Brenner, D.J., Pintilie, M., Xu, T., Chung, J., Paul, N., and Hodgson, D.C. (2007) A comparison of mantle versus involved-field radiotherapy for Hodgkin's lymphoma: Reduction in normal tissue dose and second cancer risk. Radiation Oncology 2(1):11 p.

Kleiman, N.J., David, J., Elliston, C.D., Hopkins, K.M., Smilenov, L.B., Brenner, D.J., Worgul, B.V., Hall, E.J., and Lieberman, H.B. (2007) Mrad9 and Atm haploinsufficiency enhance spontaneous and X-ray-induced cataractogenesis in mice. Radiation Research 168(5): 567-573.

Bigelow, A.W., Ross, G.J., Randers-Pherson, G., and Brenner, D.J. (2006) Session 3. Multiphoton microscope design for the Columbia University microbeam II endstation. In: Extended Abstracts: Proceedings of the 7th International Workshop: Microbeam Probes of Cellular Radiation Response.Radiation Research 166:664.

Braby, L., Brenner, D.J., Cherubini, R., Cremer, T., Durante, M., Geard, C. Kobayashi, K., Miller, J., Prise, K., and Taucher-Scholz, G. (2006) Session 1. Microbeam probes of cellular radiation response. In: Extended Abstracts: Proceedings of the 7th International Workshop: Microbeam Probes of Cellular Radiation Response.Radiation Research 166:652-653.

Brenner, D.J. (2006) Cancer risks at very low doses: Why did the US and French National Academies come to direct opposite conclusions? Environmental and Molecular Mutagenesis 47(6):403.

Brenner, D.J. and Sachs, R.K. (2006) Estimating radiation-induced cancer risks at very low doses: Rationale for using a linear no-threshold approach. Radiation and Environmental Biophysics 44:253-256.

Garty, G., Ross, G.J., Bigelow, A.W., Schettino, G., Randers-Pherson, G., and Brenner, D.J. (2006) Session 1. Status of the stand-alone microbeam at Columbia University. In: Extended Abstracts: Proceedings of the 7 th International Workshop: Microbeam Probes of Cellular Radiation Response. Radiation Research 166:656.

Sedelnikova, O.A., Nakamura, A., Kovalchuk, O., Koturbash, I., Mitchell, S.A., Marino, S.A., Brenner, D.J., and Bonner, W.M. (2006) Session 7. Long-term biological bystander effects of microbeam irradiation in 3D human tissue models. Proceedings of the 7th International Workshop: Microbeam Probes of Cellular Radiation Response.Radiation Research 166:687.

Schettino, G., Randers-Pherson, G., and Brenner, D.J. (2006) Session 2. Development of a soft x-ray microbeam at RARAF. In: Extended Abstracts: Proceedings of the 7th International Workshop: Microbeam Probes of Cellular Radiation Response.Radiation Research 166:661-662.

Ross, G.J., Ponnaiya, B., Bigelow, A.W., Randers-Pherson, G., and Brenner, D.J. (2006) Session 3. Update on incorporating no-stain imaging into microbeam endstation. In: Proceedings of the 7th International Workshop: Microbeam Probes of Cellular Radiation Response.Radiation Research 166:667-668.

Belyakov, O.V., Mitchell, S.A., Parikh, D., Randers-Pehrson, G., Marino, S.A., Amundson, S.A., Geard, C.R., and Brenner, D.J. (2005) Biological effects in unirradiated human tissue induced by radiation damage up to 1 mn away. PNAS 102(40):14203-14208.

Brenner, D.J., Hall, E.J., Curtis, R.E., and Ron, E. (2005) Prostate radiotherapy is associated with second cancers in many organs, not just the colorectum. Correspondence. Gastroenterology 129(2):773-774.

Brenner, D.J., and Mossman, K.L. (2005) Do radiation doses below 1 cGy increase cancer risks? Extended Abstracts. Radiation Research 163:692-693.

Sachs, R.K. and Brenner, D.J. (2005) Solid tumor risks after high doses of ionizing radiation. PNAS 102(37):13040-13045.

Vives, S., Loucas, B., Vazquez, M., Brenner, D.J., Sachs, R.K., Hlatky, L., Cornforth, M., and Arsuaga, J. (2005) SCHIP: statistics for chromosome interphase positioning based on interchange data. Application note. Bioinformatics 21(14):3181-3182.

Vives, S., Loucas, B., Vazquez, M., Brenner, D.J., Sachs, R.K., Hlatky, L., Cornforth, M., and Arsuaga, J. (2005) SCHIP: statistics for chromosome interphase positioning based on interchange data. Application note. Bioinformatics 21(14):3181-3182.

 

Zhou, H., Ivanov, V.N., Gillespie, J., Geard, C.R., Amundson, S.A., Brenner, D.J., Yu, Z., Lieberman, H.B., and Hei, T.K. (2005) Mechanism of radiation-induced bystander effect: Role of the cyclooxygenase-2 signaling pathway. PNAS 102(41):14641-14646.

Brenner, D.J. (2004) Comments on “Chromosome intrachanges and interchanges detected by multicolor banding in lymphocytes: Searching for clastogen signatures in the human genome”. Radiation Research 162:600-601.

Ponnaiya, B., Jenkins-Baker, G., Brenner, D.J., Hall, E.J., Randers-Pehrson, G., and Geard, C.R. (2004) Biological responses in known bystander cells relative to known microbeam-irradiated cells. Radiation Research 162:426-432.

Mitchell, C.R., Azizova, T.V., Hande, M.P., Burak, L.E., Tsakok, J.M., Khokhryakov, V.F., Geard, C.R., and Brenner, D.J. (2004) Stable intrachromosomal biomarkers of past exposure to densely ionizing radiation in several chromosomes of exposed individuals. Radiation Research 162:257-263.

Brenner, D.J. and Elliston, C.D. (2004) Estimated radiation risks potentially associated with full-body CT screening. Radiology 231(2):440-445.

Arsuaga, J., Greulich-Bodes, K.M., Vazquez, M., Bruckner, M., Hahnfeld, T.P., Brenner, D.J., Sachs, R., and Hlatky, L. (2004) Chromosome spatial clustering inferred from radiogenic aberrations. International J. of Radiation Biology 80(7):507-515.

Brenner, D.J. and Hall, E.J. (2004) Risk of cancer from diagnostic X-rays. Lancet 363:2192.

Mitchell, S.A., Marino, S.A., Brenner, D.J., and Hall, E.J. (2004) Bystander effect and adaptive response in C3H 10T1/2 cells. International J. of Radiation Biology 80(7):465-472.

Mitchell, S.A., Randers-Pehrson, G., Brenner, D.J., and Hall, E.J. (2004) The bystander response in C3H 10T1/2 cells: The influence of cell-to-cell contact. Radiation Research 161:397-401.

Zhou, H., Randers-Pehrson, G., Geard, C.R., Brenner, D.J., Hall, E.J., and Hei, T.K. (2003) Interaction between radiation-induced adaptive response and bystander mutagenesis in mammalian cells. Radiation Research 160(5):512-516.

Brenner, D.J., Doll, R., Goodhead, D.T., Hall, E.J., Land, C.E., Little, J.B., Lubin, J.H., Preston, D.L., Preston, R.J., Puskin, J.S., Ron, E., Sachs, R.K., Samet, J.M., Setlow, R.B., and Zaider, M. (2003) Cancer risks attributable to low doses of ionizing radiation: Assessing what we really know. PNAS 100(24):13761-13766.

Brenner, D.J. and Sachs, R.K. (2003) Domestic radon risks may be dominated by bystander effects--but the risks are unlikely to be greater than we thought. Health Physics 85(1):103-108.

Hande, M.P., Azizova, T.V., Geard, C.R., Burak, L.E., Mitchell, C.R., Khokhryakov, V.F., Vasilenko, E.K., and Brenner, D.J. (2003) Past exposure to densely-ionizing radiation leaves a unique permanent signature in the genome. American J. of Human Genetics 72:1162-1170.

Zhou, H., Randers-Pehrson, G., Geard, C.R., Brenner, D.J., Hall, E.J., and Hei, T.K. (2003) Interaction between radiation-induced adaptive response and bystander mutagenesis in mammalian cells. Radiation Research 160:512-516.

Brenner, D.J. and Sachs, R.K. (2002) Do low dose-rate bystander effects influence domestic radon risks? International J. of Radiation Biology 78:593-604.

Brenner, D.J. and Sachs, R.K. (2002) Bystander effects may dominate domestic radon risks--but current risk estimates are probably okay. Radiation Research 158(6):790-791.

Brenner, D.J.. Sawant, S.G., Hande, M.P., Miller, R.C., Elliston, C.D., Fu, Z., Randers-Peherson, G., and Marino, S.A. (2002) Routine screening mammography: How important is the radiation-risk side of the benefit-risk equation? International J. of Radiation Biology 78(12):1065-1069.

Cornforth, M.N., Greulich-Bode, K.M., Loucas, B.D., Arsuaga, J., Vazequz, M., Sachs, R.K., Bruckner, M., Molls, M., Hahnfeldts, P., Hlatky, L., and Brenner, D.J. (2002) Chromosomes are predominantly located randomly with respect to each other in interphase human cells. J. of Cell Biology 159(2):237-244.

Brenner, D.J. and Elliston, C.D. (2001) The potential impact of bystander effects on radiation risks in a Mars mission. Radiation Research 156:612-617.

Brenner, D.J., Elliston, C.D., Hall, E.J., and Berdon, W. (2001) Estimated risks of radiation-induced fatal cancer from pediatric computed tomography. AJR 176:289-96.

Brenner, D.J., Little, J.B., and Sachs, R.K. (2001) The bystander effect in radiation. Oncogenesis: II. A Quantitative Model Rad. Res. 155:402-08.

Brenner, D.J., Okladnikova, N., Hande, P., Burak, L., Geard, C.R., and Azizova, T. (2001) Biomarkers specific to densely-ionizing (high LET) radiations. Radiation Protection Dosimetry 97(1):69-73.

Brenner, D.J. and Raabe, O.G. (2001) Is the linear-no-threshold hypothesis appropriate for use in radiation protection? Radiation Protection Dosimetry 97(3):279-285.

Ponomarev, A.L., Cucinotta, F.A., Sachs, R.K., and Brenner, D.J. (2001) Monte Carlo predictions of DNA fragment-sized distributions for large sizes after HZE particle irradiation. Phys. Med. 17(Suppl. 1):153-156.

Ponomarev, A.L., Cucinotta, F.A., Sachs, R.K., Brenner, D.J., and Peterson, L.E. (2001) Extrapolation of the DNA fragment-size distributions in a high-dose PFGE assay to low doses. Radiation Research 156(5 Pt 2):594-597.

Randers-Pehrson, G., Geard, C.R., Johnson, G., Elliston, C.D., and Brenner, D.J. (2001) The Columbia University single-ion microbeam. Radiation Research 156:210-214.

Sawant, S., Randers-Pehrson, G., Brenner, D.J., and Hall, E.J. (2001) The bystander effect in radiation oncogenesis: I. Oncogenic transformation can be initiated in C3H10T1/2 cells in vitro in the unirradiated neighbors of irradiated cells. Radiation Research 155:397-401.

Smilenov, L.B., Brenner, D.J., and Hall, E.J. (2001) Modest increased sensitivity to radiation oncogenesis in ATM heterozygous versus wild-type mammalian cells. Cancer Research 61:5710-5713.

Brenner, D.J. (2000) Rutherford, the Curies, and radon. Med Phys. 27(3):618.

Brenner, D.J. and Sachs, R.K. (2000) Protraction effects in radiation studies: I. Basic biophysics. Extended abstract. Radiation Research 154:736-737.

Dymnikov, A.D., Brenner D.J., Johnson, G., and Randers-Pehrson, G. (2000) Theoretical study of short electrostatic lens for the Columbia ion microprobe. Rev. Sci. Instr. 71:1646-50.

Miller, R.C., Marino, S.A., Napoli, J., Shah, H., Hall, E.J., Geard, C.R., and Brenner, D.J. (2000) Oncogenic transformation in C3H10T cells by low-energy neutrons. International J. of Radiation Biology 76:327-334.

Brenner, D.J. (1999) Does fractionation decrease the risk of breast cancer induced by low-LET radiation? Radiation Research 151:225-229.

Brenner, D.J. (1999) The relative effectiveness of exposure to 131I at low doses. Health. Phys. 76:180-185.

Johnson, K.L., Brenner, D.J., Geard, C.R., Nath, J., and Tucker, J.D. (1999) Chromosome aberrations of clonal origin in irradiated and unexposed individuals: Assessment and implications. Radiation Research 152:1-5.

Johnson, K.L., Brenner, D.J., Nath, J., Tucker, J.D., and Geard, C.R. (1999) Radiation-induced breakpoint misrejoining in human chromosomes: Random or non-random? International J. of Radiation Biology 75:131-141.

Miller, R.C., Randers-Pehrson, G., Geard, C.R., Hall, E.J., and Brenner, D.J. (1999) The oncogenic transforming potential of the passage of single alpha particles through mammalian cell nuclei. Proc. Natl. Acad. Sci., U.S.A. 96(1):19-22.