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- 2006 Workshop:
Low dose ionizing radiation (IR) signaling regulation in vivo versus in vitro of the IFG-1/IGF-1R pathway leading to the synthesis of pro-survival secretory clusterin expression: Roles for p53/Hdm2.
Cataldo, E., Wilson, D., Sampath, L, Araki, S., Zou, Y., Shankar, B, Mayo, L., and Boothman, D.A.
- 2005 Workshop
Regulatory
Mechanisms of Secretory Clusterin (sCLU) Expression: A Low
Doseinducible ‘Bystander’ Cytoprotective Protein.
Criswell, T., Cataldo, E., Araki, S., Leskov,
K., Thakur, V., Sampath, L., Wilson, D., Mayo,
L., and Boothman, D.A.
-
- Secretory
Clusterin (sCLU) Expression as a Sign of Genomic Instability
and A Potential Promoter of Instability in Bystander
Cells.
Criswell, T., Beman, M., Araki, S., Leskov, K., Klokov,
D., and Boothman, D.A.
-
2002
Workshop
Synthesis
of Pro-Apoptotic Forms of Clusterin: An Ionizing Radiation-Induced
Protein.
Leskov, K.S., Li, J., Klokov, D.V., and Boothmam,
D.A.
Transcriptional
Repression of Clusterin by the p53 Tumor Suppressor Protein.
Criswell, T., Klekov, D., Lavik, J.P., Isreal, S., Leskov,
K., and Boothman, D.A.
-
2001
Workshop
Clusterin
-- A Novel p53 Repressed Secretory Protein
Criswell, T., Yangland, C.R., and Boothman, D.A.
Structure-Functional
Analysis of Clusterin: Ku70 Association and Cell Death.
Leskov, K.S., Kinsella, T.J., and Boothman, D.A.
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Publications:
Suzuki, M. and Boothman,
D.A. (2008)
Stress-induced premature senescence (SIPS). Journal of
Radiation Research 49(2):105-112.
Choi, E.K., Terai, K., Ji, I.-M., Kook,
Y.H., Park, K.H., Oh, E.T., Griffin, R.J., Lim, B.U.,
Kim, J.S., Lee, D.S., Boothman, D.A.,
Loren, M., Song, C.W., and Park, H.J. (2007) Upregulation
of NAD(P)H:quinone oxidoreductase by radiation potentiates
the effect of bioreductive [beta]-lapachone on cancer
cells. Neoplasia 9(8):634-642.
Shannan, B., Seifert, M., Boothman,
D.A., Tilgen, W.,
and Reichrath, J. (2007) Clusterin over-expression modulates
proapoptotic and antiproliferative effects of 1,25(OH)2D3
in prostate cancer cells In vitro. Journal
of Steroid Biochemistry and Molecular Biology 103(3-5):721-725.
Blanco, E., Bey, E.A., Dong, Y.,
Weinberg, B.D., Sutton, D.M., Boothman, D.A.,
and Gao, J. (2007) beta-Lapachone-containing PEG-PLA
polymer micelles as novel nanotherapeutics against
NQO1-overexpressing tumor cells. Journal
of Controlled Release 122(3):365-374.
Shannan, B., Seifert, M., Leskov,
K., Willis, J., Boothman, D.A., Tilgen,
W., and Reichrath, J. (2006) Challenge and promise:
Roles for clusterin in pathogenesis, progression
and therapy of cancer. Cell Death and Differentiation 13:12-19.
Araki, S., Israel, S., Leskov.,
K.S., Criswell, T.L., Beman, M., Klokov, D.Y., Sampalth,
L., Reinicke, K.E., Cataldo, E., Mayo, L.D., and Boothman,
D.A. (2005) Clusterin proteins: Stress-inducible
polypeptides with proposed functions in multiple organ
dysfunction. British Institute of Radiology Supplement
27:106-113.
Criswell,
T., Beman, M., Araki, S., Leskov, K., Cataldo, E.,
Mayo, L., and Boothman,
D.A. (2005) Delayed activation of IGF-1RSrc/MAPK signaling after IR
regulates clusterin expression, a pro-survival protein. J. of Biological
Chemistry 280(14):14212-14221.
Park, H.J., Ahn, K., Ahn, S., Choi, E., Lee, S.W., Williams, B., Kim, E.J., Griffin, R., Bey, E.A., Bornmann, W.G., Gao, J., Park, H.J., Boothman, D.A., and Song, C.W. (2005) Susceptibility of cancer cells to
β - lapachone is enhanced by ionizing radiation. Int. J. Radiation Oncology Biol. Phys. 61(1):212-219.
Meyers, M., Hwang, A., Wagner, M.W., and Boothman, D.A. (2004) Special section: Impact of the environment on colon cancer (II). Environmental and Molecular Mutagenesis 44:249-264.
Klokov,
D., Criswell, T., Sampath, L., Leskov, K.S., Frinkley,
K., Araki, S., Beman, M., Wilson, D.L., and Boothman,
D.A. (2003) Clusterin: A protein with multiple
functions as a potential ionizing radiation exposure
marker. International Congress Series 1258:219-232.
Klokov, D., Criswell, T., Leskov, K.S., Araki, S., Mayo,
L., and Boothman, D.A. (2004) IR-inducible
clusterin gene expression: A protein with potential
roles in ionizing radiation-induced adaptive responses,
genomic instability, and bystander effects. Mutation
Research 568(1):97-110.
Criswell,
T., Klokov, K.S., and Boothman, D.A. (2003)
IR-inducible transcriptional repression of clusterin
by the p53 tumor suppressor protein. Cancer Biology
and Therapy
2(4):25-31.
Criswell, T., Klokov, K.S., and Boothman,
D.A. (2003)
Transcriptional repression of clusterin by the p53 tumor
suppressor protein. Cancer Biology
and Therapy 2(4):25-31.
Sun,
W., Sawada, M., Hayes, P., Leskov, K., Boothman,
D.A., and Matsuyama, S. (2003) Ku70 suppresses
the apoptotic translocation of Bax to mitochondria. Nature
Cell Biology 5:320-329
Yang,
C.-R., Odegaard, E., Leskov, K., Hosley-Eberlein,
K., Criswell, T., Kinsella, T.J., and Boothman,
D.A.
(2000) Nuclear clusterin/XIP8, an X-ray induced KU70-binding
protein that signals cell death. PNAS, USA 97:5907-5912.
Criswell,
T., Leskov, K., Miyamoto, S., Luo, G., and Boothman,
D. (2003) Transcription factors activated in
mammalian cells after clinically relevant doses of
ionizing radiation. Oncogene 22(37):5813-5827.
Leskov,
K., Antonio, S., Criswell, T., Yang, C.-R., Kinella, T.J.,
and Boothman, D.A. (2001) Radiation-inducible clusterin
(CLU): A molecular switch between life and death. Radiation
Research 156(4):441-442.
Leskov, K., Criswell, T.A., Antonio, S., Li, J., Yang,
C.-R., Kinsella, T.J., and Boothman, D.A. (2001)
When X-ray-inducible proteins meet DNA double strand
break repair. Seminars in Radiation Oncology 11(4):352-372.
Leskov,
K.S., Klokov, D.Y., Li, J., Yang, C.R., Kinsella, T.J., and Boothman,
D.A. (2003) Synthesis and functional analyses
of nuclear clusterin, a cell death protein. J.
of Biological Chemistry 278(13):11590-11600.
Yan,
T., Schupp, J.E., Hwang, H.S., Wagner, M.W., Berry,
S.E., Strickfaden, S., Veigl, M.L., Sedwick, W.D., Boothman,
D.A., and Kinsella, T.J. (2001) Loss of DNA mismatch
repair imparts defective cdc2 signaling and G(2)
arrest responses without altering survival after
ionizing radiation.
Cancer Research 61(22):8290-8297.
Huang,
T.T., Wuerzberger-Davis, S.M., Seufzer, B.J., Shumway,
S.D., Kurama, T., Boothman, D.A., and Miyamoto,
S. (2000). NF- kB activation by Camptothecin: A linkage
between nuclear DNA damage and cytoplasmic signaling
events.
J. of Biological Chemistry 275(13):9501-9509.
Kalka,
K., Ahmad, N., Criswell, T., Boothman, D.A.,
and Mukhtar, H. (2000) Upregulation of clusterin
during photodynamic therapy-mediated apoptosis of
tumor cells and ablation of mouse skin tumors. Cancer
Research 60(21):5984-5987.
Yang,
C.-R., Odegaard, E., Leskov, K., Hosley-Eberlein, K.,
Criswell, T., Kinsella, T.J., and Boothman, D.A.
(2000) Nuclear clusterin/XIP8, an X-ray-induced Ku70-binding
protein that signals cell death. Proc. Natl. Acad.
Sci., U.S.A. 97(11):5907-5912.
Yang,
C.-Y., Leskov, K., Hosley-Eberlein, K.J., Criswell,
T.L., Mooney, M.A., Pink, J.J., and Boothman,
D.A.
(2000) Ku70-binding proteins. In: Radiation
Research. 11th International Congress of Radiation
Research,
Dublin, Ireland, July 18-23, 1999. M. Moriarty, C. Mothersill,
C. Seymore, M. Edington, J.F. Ward, and R.J.M. Fry (Eds.)
International Association for Radiation Research
2:426-429.
Badie,
B., Goh, C.S., Klaver, J., Herweijer, H., and Boothman,
D.A. (1999) Combined radiation and p53 gene therapy
of malignant glioma cells. Cancer Gene Therapy
6:155-162.
Mendonca,
M.S., Howard, K.L., Farrington, D.L., Desmond, L.A., Temples,
T.M., Mayhugh, B.M., Pink, J.J., and Boothman,
D.A. (1999) Delayed apoptotic responses associated
with radiation-induced neoplastic transformation of human
hybrid cells. Cancer Research 59(16):3972-3979.
Limoli, C.L., Hartmann, A., Shepard,
L., Yang, C.R., Boothman, D.A., Bartholomew,
J., and Morgan, W.F. (1998) Apoptosis,
reproductive failure, and oxidative stress in Chinese
hamster ovary cells with compromised genomic integrity.
Cancer Research 58:(16):3712-3718.
Boothman,
D.A.,
Odegaard, E., Yang, C.-R., Hosley, K., and Mendonca, M.
(1998) Molecular analyses of adaptive survival responses
(ASRs): Role of ASRs in radiotherapy. Human and
Experimental Toxicology 17:448-453.
Davis,
T.W., Meyers, M., Wilson-Van Patten, C., Sharda, N.,
Yang, C.R., Kinsella, T.J., and Boothman,
D.A. (1998) Transcriptional
responses to damage created by ionizing radiation: Molecular
sensors. In: DNA Damage and repair,
Vol. 2: DNA repair in higher eukaryotes.
J.A. Nickoloff and M.F. Hoekstra (Ed.). Totowa, NJ
: Humana Press, pp. 223-262.
Boothman,
D.A., Meyers, M., Odegaard, E., and Wang, M. (1996) Altered
G1 checkpoint control determines adaptive survival
responses to ionizing radiation. Mutation Research
358:143-153.
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