About the Program :)
















 

Joel S. Bedford
Colorado State University
E-mail:
jbedford@colostate.edu
Website: http://www.cvmbs.colostate.edu/radiology


Newly Funded Project:

Transgenerational Radiation Genetics: A feasibility Study for the Use of the Japanese Medaka to Investigate Adaptive Responses and Genomic Instability, abstract, description.

Currently Funded Projects:

Genetic Factors Affecting Susceptibility to Low Dose and Low Dose-Rate Radiation Exposure, description.

Technical Abstracts:

Publications:

Kato, T.A., Okayasu, R., and Bedford, J.S. (2008) Comparison of the induction and disappearance of DNA double strand breaks and gamma-H2AX foci after irradiation of chromosomes in G1-phase or in condensed metaphase cells. Mutation Research 639(1-2):108-112.

Nagasawa, H., Wilson, P.E., Chen, D.J., Thompson, L.H., Bedford, J.S., and Little, J.B. (2008) Low doses of alpha particles do not induce sister chromatid exchanges in bystander Chinese hamster cells defective in homologous recombination. DNA Repair 7(3):515-522.

Wilson, P.E., Nagasawa, H., Warner, C.L., Fitzek, M.M., Little, J.B., and Bedford, J.S. (2008) Radiation sensitivity of primary fibroblasts from hereditary retinoblastoma family members and some apparently normal controls: Colony formation ability during continuous low-dose-rate gamma irradiation. Radiation Research 169(5):483-494.

Chuang, E.Y., Chen, X., Tsai, M-H., Yan, H., Li, C-Y., Mitchell, J.B., Nagasawa, H., Wilson, P.F., Peng, Y., Fitzek, M.M., Bedford, J.S., and Little, J.B. (2006) Abnormal gene expression profiles in unaffected parents of patients with hereditary-type retinoblastoma. Cancer Research 66(7):3428-3433.

Hinz, J.M., Tebbs, R.S., Wilson, P.F., Nham, P.B., Saalazar, E.P., Nagasawa, H., Urbin, S.S., Bedford, J.S., and Thompson, L.H. (2006) Repression of mutagenesis by Rad51D-mediated homologous recombination. Nucleic Acids Research 34(5):1358-1368.

Kato, T.A., Nagasawa, H., Weil, M.M., Genik, P.C., Little, J.B., and Bedford, J.S. (2006) γ-H2AX foci after low-dose-rate irradiation reveal Atm haploinsufficiency in mice. Radiation Research 166(1):47-54.

Kato, T.A., Nagasawa, H., Weil, M.W., Little, J.B., and Bedford, J.S. (2006) Levels of γ-H2AX foci after low-dose-rate irradiation reveal a DNA DSB rejoining defect in cells from human ATM heterozygotes in two AT families and in another apparently normal individual. Radiation Research 166(3):443-453.

Yan, B., Wang, H., Peng, Y., Hu, Y., Wang, H., Zhang, X., Chen, Q., Bedford, J.S., Dewhirst, M.W., and Li, C. ( 2006) A unique role of the DNA fragmentation factor in maintaining genomic stability. PNAS 103(5):1504-1509.

Nagasawa, H., Peng, Y., Wilson, P.F., Lio, Y.-C., Chen, D.J., Bedford, J.S., and Little, J.B. (2005) Role of homologous recombination in the alpha-particle-induced bystander effect for sister chromatid exchanges and chromosomal aberrations. Radiation Research 164:141-147.

Peng, Y., Woods, R.G., Beamish, H., Ye, R., Lees-Miller, S.P., Lavin, M.F., and Bedford, J.S. (2005) Deficiency in the catalytic subunit of DNA-dependent protein kinase causes down-regulation of ATM. Cancer Research 65(5):1670-1677.

Hinton, T.G., Bedford, J.S., Congdon, J.C., and Whicker, F.W. (2004) Effects of radiation on the environment: A need to question old paradigms and enhance collaboration among radiation biologists and radiation ecologists. Radiation Research 162:332-338.

Bedford, J.S.
(2003) Letters to the Editor Re: Target theory and Timofeeff-Ressovsky. Radiation Research 159:135.

Coleman, C.N., Stone, H.B., Alexander, G.A., Barcellos-Hoff, M.H., Bedford, J.S., Bristow, R.G., Dynlacht, J.R., Fuks, Z., Gorelic, L.S., Hill, R.P., Joiner, M.C., Liu, F.-F., McBride, W.H., Mckenna, W.G., Powell, S.N., Robbins, M.E.C., Rockwell, S., Schiff, P.B., Shaw, E.G., Siemann, D.W., Travis, E.L., Wallner, P.E., Wong, R.S.L., and Zeman, E.M. (2003) Education and training for radiation scientists: Radiation Research Program and American Society of Therapeutic Radiology and Oncology Workshop, Bethesda, Maryland, May 12-14, 2003. Radiation Research 160:729-737

Dugan L.C. and Bedford, J.S. (2003) Are chromosomal instabilities induced by exposure of cultured normal human cells to low- or high-LET radiation? Radiation Research 159:301-311.

Takahashi, S., Hiroshi, S., Yoshihisa, K., Hiroshi, U., Bedford, J.S., and Ryuichi, O. (2002) Inhibition of DNA-double strand break repair by antimony compounds. Toxicology 180(3,2):249-256.

Peng, Y., Zhang, Q., Nagasawa, H., Okayasu, R., Liber, H.L., and Bedford, J.S. (2002) Silencing expression of the catalytic subunit of DNA-dependent protein kinase by small interfering RNA sensitizes human cells for radiation-induced chromosome damage, cell killing and mutation. Cancer Research 62:6400-6404.

 



                   
                   
                   
 

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