Venkatachalam, P., de Toledo, S., Pandey,
B., Tephly, L.A., Carter, A.B., Little,
J.B., Spitz, D.R.,
and Azzam, E.I. (2008) Regulation of normal cell cycle progression
by flavin-containing oxidases. Oncogene 27(1):20-31.
Venkatachalam, P., de Toledo, S., Pandey,
B., Tephly, L.A., Carter, A.B., Little, J.B., Spitz,
D.R.,
and Azzam, E.I. (2008) Regulation of normal
cell cycle progression by flavin-containing oxidases. Oncogene 27(1):20-31.
de Toledo, S. M., and Azzam E. I. (2006) Adaptive and bystander responses in human and rodent cell cultures exposed to low level ionizing radiation: The impact of linear energy transfer. Dose-Response 4(4):291-301.
de Toledo, S.M., Asaad, M., Venkatachalam,
P., Li, L., Howell, R.W., Spitz, D.R., and Azzam,
E.I.(2006) Adaptive response to low-dose/low-dose-rate γ rays
in normal human fibroblast: The role of growth architecture
and oxidative metabolism. Radiation Research 166:849-857.
Little, J.B., Azzam, E.I., de
Toledo, S.M., and Nagasawa, H. (2005) Characteristics and
mechanisms of the bystander response in monolayer cell cultures
exposed to very low fluences to alpha particles. Radiation
Physics and Chemistry 72:307-313.
Venkatachalam, P., de Toledo, S.M.,
and Azzam, E.I. (2005) Flavin-containing oxidases
regulate progression from G 1 to S phase of the cell cycle
in normal human diploid fibroblasts. Radiation Physics
and Chemistry 72:315-321.
Azzam, E.I. and Little,
J.B. (2004) The radiation-induced bystander effect:
Evidence and significance. Human & Experimental
Toxicology 23:61-65.
Spitz, D.R., Azzam, E.I., Li,
J.J., and Gius, D. (2004) Metabolic oxidation/reduction
reactions and cellular responses to radiation: A unifying
concept in stress response biology. Cancer and Metastasis
Reviews 23:311-322.
Azzam, E.I., Nagasawa,
H., Yu, Y., Li, C.-Y., and Little, J.B. (2002)
Cell cycle deregulation and xeroderma pigmentosum group C
cell transformation. The Society for Investigative Dermatology 119(6):1350-1354.
Azzam, E.I., de Toledo,
S.M., Waker, A.J., and Little, J.B. (2000)
High and low fluences of α-particles induce a G 1 checkpoint
in human diploid fibroblasts. Cancer Research 60:2623-2631.
Dahlberg, W.K., Azzam, E.I., Yu,
Y., and Little, J.B. (1999) Response of
human tumor cells of varying radiosensitivity and radiocurability
to fractionated irradiation. Cancer Research 59: 5365-5369.
Mitchel, R.E.J., Azzam, E.I., and
DeToledo, S.M. (1997) Adaption to ionizing radiation in mammalian
cells. In: Stress-inducible
processes in higher eukaryotic cells, Kova (Ed.). New
York: Plenum Press.
Azzam, E.I. , de Toldeo,
S.M., and Little, B.J. (2004) Stress signaling from irradiated
to non-irradiated cells. Current Cancer Drug Targets 4(1):53-64.
Azzam,
E.I. (2004)
Radiation induced adaptive and bystander effects in human
and rodent cells exposed to low dose/fluence ionizing
radiation. In: The 14th Pacific Basin Nuclear Conference,
Honolulu, Hawaii.
Neti, P.V.S.V., de Toledo, S.M., Perumal,
V., Azzam,
E.I., and Howell, R.W. (2004) A multi-port low-fluence
alpha-particle irradiator: Fabrication, testing and benchmark
radiobiological studies. Radiation Research 161(6):732-738.
Azzam,
E.I., de Toledo, S.M., and Little, J.B. (2003)
Oxidative metabolism, gap junctions and the ionizing radiation-induced
bystander effect. Oncogene 22:7050-7057.
Mamon,
H.J., Dahlberg, W., Azzam, E.I., Nagasawa,
H., Muto, M.G. and Little, J.B. (2003)
Differing effects of breast cancer 1, early onset (BRCA1)
and ataxia-telangiectasia mutated (ATM) mutations on
cellular responses to ionizing radiation. Radiation
Biology 79(10):817-830.
Azzam,
E.I., de Toledo, S.M., and Little, J.B. (2003)
Expression of CONNEXIN43 is highly sensitive to ionizing
radiation and other environmental stresses. Cancer
Research 63:7128-7135.
Little, J.B., Azzam, E.I., de
Toledo, S.M., and Nagasawa, H. (2002) Bystander effects:
Intercellular transmission of radiation damage signals. Radiation
Protection Dosimetry 99(1-4):159-162.
Little, J.B., Nagasawa,
H., de Toledo, S.M., and Azzam, E.I. (2002)
Transmission of damge signals from irradiated to nonirradiated
cells. International
Congress Series 1236:229-235.
Azzam,
E.I., de Toledo, S.M., Spitz, D.R., and Little, J.B.
(2002) Oxidative metabolism modulates signal transduction
and micronculeus formation in bystander cells from alpha-particle-irradiated
normal human fibroblast cultures. Cancer Research 62:5436-5442.
Azzam, E.I., de Toledo,
S.M., Waker, A.J., and Little, J.B. (2000)
High and low fluences of α-particles induce a G 1
checkpoint in human diploid fibroblasts. Cancer Research 60:2623-2631.
Azzam,
E.I., de Toledo, S.M., Raaphorst, G.P., and
Mitchel, R.E. (1996) Low-dose ionizing radiation decreases
the frequency of neoplastic transformation to a level
below the spontaneous rate in C3H 10T1/2 cells. Radiation
Research 146(4):369-373.
Schöllnberger,
H., Mitchel, R.E., Azzam, E.I., Crawford-Brown,
D.J., and Hofmann, W. (2002) Explanation of protective
effects of low doses of y-radiation with a mechanistic
radiobiological model. International J. of Radiation
Biology 78(12):1159-1173.
Azzam, E.I., de Toledo,
S.M., and Little,
J.B. (2001) Direct evidence for the participation
of gap junction-mediated intercellular communication in
the transmission of damage signals from a-particle irradiated
to nonirradiated cells. PNAS 98(2):473-478.
Azzam, E.I., de
Toledo, S.M., Gooding, T., and Little, J.B (1998)
Intercellular communication is involved in the bystander
regulation of gene expression in human cells exposed to very
low fluences of alpha particles. Radiation Research 150(5):497-504.
Azzam, E.I., Raaphorst,
G.P., and Mitchel, R.E.J. (1994) Radiation-induced adaptive
response for protection against micronucleus formation and
neoplastic transformation in CsH 10T1/2 mouse embryo cells. Radiation
Research 138(1 Suppl):S28-S31.
