About the Low Dose Radiation Research Program

	New & Currently Funded Projects Effects of Low Doses of Radiation DNA Repair Eric Ackerman eackerman@pnl.gov Pacific Northwest National Laboratory Cellular Responses to Low Dose/Very High Dose-rate Ionizing Radiation: the Role of Endogenous Oxidative Metabolism Edouard Azzam aazzamei@umdnj.edu UMDNJ- New Jersey Medical School Identification of Mouse Genetic Susceptibility to Radiation Carcinogenesis An expression Array Strategy to Identify Mouse Strain-Specific DNA Damage Response Pathways in Mammary Tissue Allan Balmain abalmain@cc.ucsf.edu University of California, San Francisco An expression Array Strategy to Identify Mouse Strain-Specific DNA Damage Response Pathways in Mammary Tissue Mechanisms of Tissue Response to Low Dose Radiation Multidimensional Analysis of Human Epithelial Cell Response to Low Dose Radiation Mary Helen Barcellos-Hoff mhbarcellos-hoff@lbl.gov Lawrence Berkeley National Laboratory Impact of Genetic Factors on the Heritable Effects of Paternal Exposure to Low-Dose Radiation Janet Baulch jebaulch@ucdavis.edu University of California, Davis Transgenerational Radiation Genetics: A feasibility Study for the Use of the Japanese Medaka to Investigate Adaptive Responses and Genomic Instability Genetic Factors Affecting Susceptibility to Low Dose and Low Dose-Rate Radiation Exposure Joel Bedford jbedford@colostate.edu Colorado State University Multi-cellular Crosstalk in Radiation Damage Eleanor Blakely eablakely@lbl.gov Lawrence Berkeley National Laboratory Clusterin: A Low Dose IR-Inducible Molecular Switch Between Life and Death David A Boothman dab30@po.cwru.edu Case Western Reserve University The Adaptive Response in p53 Cancer-prone Mice: Loss of Heterozygosity and Chromosome Instability Douglas Boreham boreham@mcmaster.ca McMaster University mFISH Measurements of Chromosomal Aberrations in Individuals Exposed in Utero to Gamma-Ray Doses from 5-20 cGy Studies of Bystander Effects in 3-D Tissue Systems Using a Low-LET Microbeam Is Increased Low-Dose Radiosensitivity Associated with Increased Transgenerational Germline Mutation Radiosensitivity? Significance of the Bystander Effect: Modeling, Experiments, and More Modeling The Risk of Cancer Induction Due to Routine Mammographic Screening David Brenner djb3@columbia.edu Columbia University Optimizing the Scientific, Regulatory, and Societal Impact of the DOE Low Dose Radiation Research Program Antone Brooks tbrooks@tricity.wsu.edu Washington State University Tri-Cities Cellular and Molecular Studies of Radio-Adaptive Responses Judith Campisi JCampisi@lbl.gov Lawrence Berkeley National Laboratory Mechanistic Modeling of Bystander Effects: An Integrated Theoretical and Experimental Approach Aloke Chatterjee A_Chatterjee@lbl.gov Lawrence Berkeley National Laboratory Low Dose Radiation Induced Proteomic Responses in Mammalian Cells David Chen DHChen@lbl.gov Lawrence Berkeley National Laboratory Genome-Scale Modeling of Low Dose Irradiation Responses Using Micro array Based Gene Networks Matthew Coleman coleman16@llnl.gov Lawrence Livermore National Laboratory Mechanisms of Low-dose Inducible DNA Repair and Adaptive Response Priscilla Cooper pkcooper@lbl.gov Lawrence Berkeley Laboratory Cytogenetic Response to Low Doses of Ionizing Radiation Michael Cornforth mcornfor@utmb.edu University of Texas Medical Branch Molecular Energetics of Clustered Damage Sites Michael Dupuis michel.dupuis@pnl.gov Pacific Northwest National Laboratory Low Dose Radiation Damage and Radioprotection in the Vertebrate Embryo William Dynan wdynan@mail.mcg.edu Medical College of Georgia A Variable Energy Soft X-ray Microprobe to Investigate Mechanisms of the Radiation-Induced Bystander Effect Melvyn Folkard folkard@graylab.ac.uk Gray Cancer Institute Low Dose Response of Respiratory Cells in Intact Tissues and Reconstituted Tissue Constructs John R. Ford ford@ne.tamu.edu Texas A & M University A Functional Genomics Approach Using Radiation-Induced Changes in Gene Expression to Study Low Dose Radiation Effects In Vitro and In Vivo Albert J.Fornace, Jr. fornace@nih.gov National Cancer Institute, National Institutes of Health Defining a Possible Low LET Bystander Effect Charles Geard crg4@columbia.edu Columbia University Comparison of Risk Estimates Based on a Variety of Risk AssessmentMethodologies Lois Swirsky Gold LSGold@lbl.gov Lawrence Berkeley National Laboratory Effects of Low Dose Ionizing Radiation on Gene Expression in Human Subjects Undergoing Radiotherapy Zelanna Goldberg zelanna.goldberg@ucdmc.ucdavis.edu University of California, Davis Genomic Instability Induced by a Bystander Signal Low Dose Ionizing Radiation-Induced Effects in Irradiated and Unirradiated Cells: Pathways Analysis in Support of Risk Assessment Ed Goodwin goodwin_edwin_h@lanl.gov Los Alamos National Laboratory Low Dose Gamma Irradiation Potentiates Secondary Exposure to Gamma Rays or Protons in Thyroid Tissue Analogs Lora M. Green lgreen@dominion.llumc.edu Loma Linda University Genetic Control of Repair and Adaptive Responses to Low-level DNA Damage James Haber haber@hydra.rose.brandeis.edu Brandeis University Individual Genetic Susceptibility Mechanisms of the Bystander Effects Eric Hall ejh1@columbia.edu Columbia University SATB1 Deficiency Accounts for High Susceptibility to Low Dose Radiation Terumi Kohwi-Shigamatsu TKohwi-Shigematsu@lbl.gov Lawrence Berkeley National Laboratory A Quantitative Assessment of Bystander Mutagenesis in the Mouse Mammary Gland In vivo Amy Kronenberg a_kronenberg@lbl.gov Lawrence Berkeley National Laboratory Molecular Characterization of the Role of SOD Genes in Mammalian Cellular Response to Low Dose Ionizing Chaun-Yuan Li cyli@radonc.duke.edu Duke University Medical Center Regulation of NF-kB and Mn SOD in Low Dose Radiatoin Induced Adaptive Responses in Mouse and Human Skin Cells Jian Jian Li jjli@coh.org City of Hope National Medical Center Molecular Mechanisms of Radiation-Induced Genomic Instability in Human Cells Howard Liber hliber@colostate.edu Colorado State University Models for the Generation of Bystander Effects by Low Doses of Ionizing Radiation John Miller jhmiller@tricity.wsu.edu Washington State University Tri-Cities Genetic Factors Affecting Susceptibility to Low-Dose Radiation Mechanisms of Adaptive Responses and Genomic Instability Induced by Low Dose/ Low Dose Rate Radiation William Morgan WFMorgan@som.umaryland.edu University of Maryland Real-Time Molecular Study of Bystander Effect Using Living Cell Imaging and Nanaparticles Optics Molecular Characterization of Survival Advantage, Bystander Effect, and Genomic Instability after Low-LET Low Dose Radiation Exposure Mohan Natarajan natarajan@uthscsa.edu University of Texas Health Science Center Methods for Deriving Gene and Pathway Specific Dose Response Curves from Expression Experiments Using DNA Microarrays David Nelson nelson6@llnl.gov Loma Linda University Mechanisms(s) of Three-Dimensional Intercellular Signaling in Mammary Epithelial Cells in Response to Low Dose, Low-LET Radiation: Implications for the Radiation-Induced Bystander Effects Lee Opresko lee.opresko@pnl.gov Pacific Northwest National Laboratory Bystander and Adaptive Responses in Tissue Models Exposed to Low Radiation Doses Kevin Prise prise@gci.ac.uk Gray Cancer Institute Low Dose Suppression of Neoplastic Transformation In vitro Mechanisms Underlying the Adaptive Response against Spontaneous Neoplastic Transformation Induced by Low Doses of Low LET Radiation J. Leslie Redpath jlredpat@uci.edu University of California, Irvine Genetic Variation in Tissue Responses to Low-dose Radiation Eugene Rinchik rinchikem@ornl.gov Oak Ridge National Laboratory Induction of Genomic Instability In Vivo by Low Doses of 137Cs Gamma Rays Kanokporn Rithidech krithid@path.som.sunysb.edu University of New York at Stony Brook Transcriptional and Radio-adaptive Responses to Low Dose Rate Environmental Exposures to The Radioactive Fallout at Chornobyl Brenda Rodgers brodgers@mail.wtamu.edu West Texas A&M University Cytogenetic tests of Radiobiological Models Relating Epidemiologically Measurable Risks to Low-Dose Risks Rainer Sachs sachs@math.berkeley.edu University of California, Berkeley Quantification of Repair of Low-Dose-Induced DNA Double-Strand Breaks in Diploid Human Cells David Schild DSchild@lbl.gov Lawrence Berkeley National Laboratory Advanced Computational Approaches for characterizing Stochastic Cellular Responses to Low-Dose, Low-Dose-Rate Exposures Bobby Scott BScott@Lrri.org Lovelace Biomedical & Environmental Research Institute Regulated Proteolysis and Bystander Effects in Radiation David Springer david.springer@pnl.gov Pacific Northwest National Laboratory Kinetic Modeling of Damage Repair, Genome Instability, and Neoplastic Transformation Robert D. Stewart trebor@purdue.edu Purdue University DNA Damage Clusters in Low level Radiation Response of Human Cells Betsy Sutherland bms@bnl.gov Brookhaven National Laboratory The Role of Somatic Intrachromosomal Recombination in Response to Low-Dose x-Radiation Induced Genetic Damage Pamela Sykes pam.sykes@flinders.edu.au Flinders University of South Australia Assessing Biological Function of DNA Damage Response Genes (2) Larry H. Thompson thompson14@llnl.gov Lawrence Livermore National Laboratory Modeling the Physics of Damage Cluster Formation in a Cellular Environment Larry H. Toburen toburenl@mail.ecu.edu East Carolina University Genetic Mechanisms of Induced Chromosomal Instability and their Relationships with Radiation Tumorigenesis Robert Ullrich bullrich@colostate.edu Colorado State University The Characterization of Genetic Responses to Low Dose Radiation Using a Genome-Wide Insertional Mutagensis Approach Katherine Vallis Katherine.vallis@rmp.uhn.on.ca Princess Margaret Hospital Post-Translational Modifications of DNA Damage Response Proteins as a Measure of Cellular Response to Low Doses of Ionizing Radiation Raymond Leon Warters ray.warters@hsc.utah.edu University of Utah Health Sciences Center Murine Models of Radiation Sensitivity Michael Weil sa64001@odin.mdacc.tmc.edu University of Texas, MD Anderson Cancer Center Monte Carlo Track Structure Simulations for Low-LET Selected Cell Radiation Studies Walter E. Wilson wwilson@tricity.wsu.edu Washington State University Tri-Cities Low-LET Radiation Studies on the Protective Bystander Effect in an Organized Tissue Basil Worgul bvw1@columbia.edu Columbia University Molecular Mechanisms and Cellular Consequences of Low-Dose Exposures to DNA-Damaging Agents Andrew J. Wyrobek wyrobek1@llnl.gov Lawrence Livermore National Laboratory BIO-BASED RISK MODELING 03-20 Use of Computational Modeling to Evaluate Hypotheses About the Molecular and Cellular Mechanisms of Bystander Effects Rory Conolly Rconolly@ciit.org Website: http://www.ciit.org/Researchers/rconolly Chemical Institute for Industrial Toxicology Research Triangle Park, NC 27709 Use of a State-Vector Model of Radiation Carcinogenesis to Integrate Information from In vitro, In vivo, Epidemiological and Physiological Studies Douglas Crawford-Brown douglas_crawford-brown@unc.edu Website: http://www.unc.edu/~dcrawfor/doug.htm University of North Carolina Chapel Hill, NC 27599 Biologically-Based Risk Modeling with a Focus on Cellular Repair Mechanisms for Radiation-Induced Damage Robert Goble rgoble@clarku.edu Website: http://www.clarku.edu/departments/idce/faculty/goble.cfm Clark University Worcester, MA 01610 Multi-level Kinetic and Dynamic Biologically Based Risk Models for Low Dose Radiation William Griffith Griffith@u.washington.edu Website: http://depts.washington.edu/chc/riskchar.html University of Washington Seattle, WA 98105 Biologically-Based Multistage Modeling of Radiation Effects William Hazelton hazelton@fhcrc.org Fred Hutchinson Cancer Institute Seattle, WA 98105 Modeling the Interrelations Among Radiation-Induced Bystander Effects, Genomic Instability, and Cancer Rainer Sachs sachs@math.berkeley.edu Website: http://math.berkeley.edu/~sachs/ University of California-Berkeley Berkley, CA 74720 Biological-Based Modeling of Low Dose Radiation Risks Advanced Computational Approaches for characterizing Stochastic Cellular Responses to Low-Dose, Low-Dose-Rate Exposures Bobby Scott BScott@Lrri.org Lovelace Biomedical & Environmental Research Institute Towards Constructing and Testing a Virtual Tissue Robert Stewart trebor@purdue.edu Website: http://www.healthsciences.purdue.edu/faculty/stewart.html Purdue University West Lafayette, IN 47907-2051 Return to the top

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